The Encyclopedia of DNA Elements (ENCODE) Data Coordinating Center (DCC) has produced a set of high-quality analysis pipelines that are used by the ENCODE Consortium and have been released to the community. The pipelines are described with the Workflow Description Language (WDL) and use containerization to enhance reproducibility. To increase the usability and dissemination of these pipelines further we have developed a web interface on Truwl (https://truwl.com/) for specifying parameters and inputs for the ENCODE atac-seq pipeline. The pipeline can be executed directly from the web interface on Google Cloud Platform (GCP). Once compute jobs are successfully executed, the analysis is posted back to Truwl to allow others to view the parameters, inputs, and outputs of previously executed pipelines. Automatically posting previously executed jobs provides increased transparency of computational experiments and provides examples for others to follow. All content on Truwl is open-access, web-searchable, and has unique identifiers making it easy to find and easy to share. In this software demonstration we will show the use of the atac-seq pipeline from Truwl by both specifying the parameters and inputs from the web interface individually and reusing a previously posted analysis.
