My main research line concerns the molecular aspects that underlie the processes of human development and aging, and their effects on oncogenic transformation. In detail, my studies regard the mutual influences between [1] repeated sequences (LINE-1, ALU, et cetera), [2] ncRNAs (circular RNAs, Chromatin associated RNAs, et cetera), [3] nuclear lamins, with particular emphasis on Hutchinson Gilford progeria Syndrome (HGPS), [4] chromatin remodeling, nuclear architecture and epigenetic modifications, [5] functional cell states (identity, stemness and senescence), [6] stem cell and cancer microenvironment, [7] endocrine function, [8] microbiota and environmental stress. The final aim of my studies is to identify, in the context of personalized medicine, diagnostic and prognostic biomarkers, preferably from liquid biopsies, and specific therapeutic targets for cancer and aging related diseases.